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Center of Excellence for Emerging and Zoonotic Animal Diseases

Pathogen of the Month



May Pathogen of the Month:



What is it? Ebola Virus

The World Health Organization describes Ebola as a severe, often fatal viral disease. Ebola first appeared in 1976 in Africa near the Ebola River, giving the illness its name. Symptoms include the sudden onset of fever fatigue, muscle pain, headache and sore throat. The disease can be difficult to distinguish from other infectious viruses. The virus has also shown some ability to persist and therefore be passed along by patients who have recently recovered from its effects.

What causes its spread?

Ebola is transmitted to humans from wild animals, the most likely source being the fruit bat. Those bats are believed to be the source of infection, transmitting the virus to chimpanzees, gorillas, monkeys, forest antelopes and porcupines, who in turn pass it to humans through close contact with blood, organs, secretions or other bodily fluids. But it can also be spread via human-to-human transmission by direct contact and eventually by sexual contact.

Ebola Virus Path - Human Being

How widespread is it?

The most recent serious outbreak was in 2014-16 in West Africa, its range extending from Guinea to Sierra Leone and Liberia. More than 28,000 cases were reported in those three nations alone with an estimated 11,310 fatalities.

What is CEEZAD doing about it?

The December 2017 edition of Medecine et Sante Tropicale includes an article co-written by Dr. Jean Paul Gonzalez, CEEZAD’s deputy director, on recent developments in the effort to contain Ebola.


Sources: WHO, CEEZAD.org, epainassist.com, NewsnViews.


April Pathogen of the Month:




What is it?   Leishmaniasis-affected Leg

The World Health organization describes leishmaniasis as a disease caused by the protozoan Leishmania parasites transmitted by the bite of infected female phlebotomine sandflies. There are three main forms of leishmaniases – visceral (also known as kala-azar and the most severe form of the disease), cutaneous and mucocutaneous, the most common. The disease affects some of the poorest people on earth, and is associated with malnutrition, population displacement, poor housing, a weak immune system and lack of financial resources.    

What causes its spread?

Leishmaniasis is linked to environmental changes that disturb the ecosystem of the sandfly vectors such as deforestation, building of dams, irrigation schemes, and urbanization.

  Leishmaniasis Map

How widespread is it?

 The WHO estimates that 700,000 to 1 million new cases occur annually, with between 20,000 and 30,000 deaths worldwide.


Have outbreaks occurred recently?

Yes. In March, a medical organization documented about 35,000 cases of infection with leishmaniasis in northern and central Syria. Last year, about 70 cases of visceral leishmaniasis, also known as the black fever, were diagnosed in Syria.

What is CEEZAD doing about it?

The March 2018 edition of the American Journal of Tropical Medical Hygiene included an article co-written by Dr. Jean Paul Gonzalez, CEEZAD’s deputy director, on the causes of leishmaniasis infection in Libya. In the paper’s abstract, the article’s authors report on findings from their screening of sandflies for leishmanial DNA.


Sources: OIE, WHO, CMAJ, Pasteur Institute, Libyan National Center For Disease Control, University of Sabratha, University of Tripoli.


March Pathogen of the Month:



Hantavirus in Brief 

What is it?

Hantavirus Pulmonary Syndrome, known more simply as hantavirus, is a severe and potentially fatal respiratory disease in humans. It is carried by rodents, making it a potential threat even to those living in homes. Human-to-human transmission has not yet been reported in the United States, although rare cases of human-to-human transmission have been reported elsewhere.




Where is hantavirus

The Centers For Disease Control has been monitoring hantavirus infections since 1993; to date, more than 700 cases have been reported, 16 of them in Kansas. The virus appears to be more widespread in South America, with individual and small clusters of cases reported in nine nations on that continent. Large outbreaks are rare, but they can be serious. Scientists have listed the mortality rate from hantavirus at 38 per cent. Last year an outbreak in Washington state claimed three lives. Hantavirus extends worldwide and shows different clinical presentations and severities (see map). These presentations include HCPS and HFRS.It is most commonly found in rural areas with abundant forests, fields and farms for the rodent host.

Hantavirus Map


Humans are most at risk when they engage in activities with the potential to put them in contact with rodent urine, droppings, saliva or nesting materials. This can include sweeping and dusting. Opening or cleaning cabins, outbuildings and other structures closed for the winter can also present concerns. Campers and hikers can also be exposed. Hantavirus symptoms include fatigue, fever and muscle pains, particularly in the large muscle groups. These can be accompanied by headaches, dizziness, chills and abdominal pain, nausea, vomiting, and diarrhea.

Are there current outbreaks?

Yes. In January and February the nation of Chile reported five cases of hantavirus infection, one of them fatal.  In February, an Arizona woman contracted a disease subsequently diagnosed as hantavirus. Cases have also recently been reported in New Mexico and Colorado.A 2017 outbreak of Seoul virus infection, a version of hantavirus, was identified in 31 infected ratteries in 11 states, among them Iowa and Colorado. Seventeen human infections were reported.

Sources: CEEZAD; Centers for Disease Control; Reuters



February Pathogen of the Month:

Crimean Congo Hemorrhagic Fever


What is it?Crimean-Congo Hemorrhagic Fever

Crimean Congo hemorrhagic fever is a disease that causes severe bleeding in humans and animals. The virus, which is carried by ticks, kills 10 to 40 percent of its victims. It can also be transmitted to people through direct contact with infected animal blood or tissues. Human-to-human transmission is possible due to close contact with secretions from infected persons. Symptoms include fever, muscle ache, dizziness, neck pain, headache and light sensitivity. Nausea, vomiting and diarrhea also occur.

Distribution Map

Where is Crimean Congo hemorrhagic fever?

CCHF is endemic in Africa, the Balkans, the Middle East, and various Asian countries south ofthe 50th parallel north -- the present geographical limit of the principal tick vector. It has not yet established an ongoing presence in Western Europe, although researchers believe that could happen absent effective control strategies.  The hosts of the CCHF virus include a wide range of wild and domestic animals such as cattle, sheep, and goats. For this reason, animal herders, hunters, livestock workers and slaughterhouse workers are viewed as being particularly at risk.

 Is it a threat to humans?

Very much so. In January of 2018, an outbreak of what is known in Africa as 'Bleeding Eye Fever' killed four and infected dozens in South Sudan, Uganda and other areas of east Africa. In South Sudan, health chiefs warned that the spread could be "catastrophic". Up to 60 people were suspected to be infected, and were undergoing tests by a team from the Sudanese health ministry and the World Health Organization. It is difficult to prevent or control CCHF infection in animals as the tick-animal-tick cycle usually goes unnoticed and the infection in domestic animals is usually not apparent. Furthermore, the tick vectors are numerous and widespread, so tick control with chemicals is only a realistic option for well-managed livestock production facilities. In a possible response to climate change, tick vectors also appear to be moving westward from their historical distributions toward wetter environments.

What is CEEZAD doing about Crimean Congo hemorrhagic fever?

CEEZAD scientists have partnered with and support the research of Dr. Huseyin Yilmaz, a veterinarian at Istanbul Veterinary School in Turkey, whose work includes research into the epidemiology of CCHF.

Sources: World Health Organization, Centers For Disease Control, slideshare.net.


January Pathogen of the Month:

Avian Influenza

What is it?

Avian influenza is the infection of birds with the Type A strain of the influenza virus. This virus is endemic worldwide, and can infect both domestic and wild avian species. Avian influenza A is very contagious among birds via nasal, salivary or fecal secretions. With particular respect to domestic birds, avian influenza is a concern for several reasons. The most significant is the potential economic impact on the food animal chain. A second reason is the potential for trade restrictions put into place out of concern for such economic impact. The third reason is the possibility that avian influenza A viruses could be transmitted to humans.

Where is avian influenzaChickens

Outbreaks of avian influenza have been reported worldwide. In December of 2017 alone, there were significant outbreaks in China, South Korea, Taiwan, Cambodia and Netherlands.

Its economic impact

The Food and Agriculture Organization estimates that since 2003, global losses from avian influenza outbreaks have run into the billions of dollars.  That economic impact depends on the speed with which it is controlled, the extent of its spread, the role played by poultry in the GDP of the affected nation, and the structure of the poultry sector. A 2003 outbreak resulted in the deaths of 44 million birds in Vietnam and 29 million in Thailand, respectively 17.5 and 14.5 percent of those nations’ bird populations.

In the United States, a 2014-15 outbreak of avian influenza affected a reported 49.7 million birds from 211 commercial flocks and 21 backyard flocks, mostly but not entirely in Minnesota and Iowa. That outbreak caused an 11 percent reduction in the egg supply, increasing the cost of a dozen eggs from $1.36 in January to $2.06 in July.

How Infected Backyard Poultry Could Spread Bird Flu to People


Threat to humans

The CDC considers the risk of avian influenza to human health to be low at present. It recommends, however, that people should observe wild birds only from a distance, avoid contact with domestic birds that appear ill or that have died, and avoid contact with surfaces that appear to be contaminated with fecal matter from wild or domestic birds.


What is CEEZAD doing about avian influenza?

Researchers supported by CEEZAD have developed live and inactivated Newcastle Disease virus-vectored vaccine candidates protecting chickens against the avian influenza virus. The vaccines were shown to be protective against novel H5NX strains for the recent outbreak in the U.S.


Sources: CEEZAD; Centers for Disease Control; Applied Commodity Price Analysis, Forecasting and Market Risk Management; Food and Agriculture Organization.