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Center of Excellence for Emerging and Zoonotic Animal Diseases

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CEEZAD

KSU Office Park
1800 Kimball Ave
Suite 130
Manhattan, KS  66502

785-532-2793   
785-532-3373 fax
CEEZAD@ksu.edu

 

The Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD) at Kansas State University was established in 2010 to help protect the nation’s agricultural and public health sectors against high-consequence foreign animal, emerging and zoonotic disease threats. CEEZAD has four principal missions:

  • Development of novel, safe, efficacious and DIVA-compatible vaccines for prevention and control of high-impact emerging and zoonotic diseases that can be manufactured in the U.S.
  • Development and expansion of technologies and platforms for laboratory and point-of-need pathogen detection.
  • Development of models to predict high-consequence disease behavior in the U.S. to aid prevention or outbreak control.
  • Development of education and training programs for students, veterinarians, first responders and researchers in high-impact animal diseases and animal emergencies.

 News/Events Highlights

April 23, 2019

Ten selected for CEEZAD BSL-3 Summer Workshop Training

Ten students from among 34 applicants have accepted invitations to take part in CEEZAD’s BSL-3 Summer Training Workshop this coming June.

The Workshop will be held June 3-13 in Manhattan and Kansas City. Participants will receive training in animal disease response, biosecurity, biodefense and select agent regulation. They will also be schooled in proper procedures to be followed in a BSL-3 laboratory environment.

They will engage in group project work, in a discussion of large animal necropsy procedures, emergency procedures, cybersecurity and related topics.

They will also hear from experts in various aspects of emerging and zoonotic diseases.

The Workshop is an annual exercise in which CEEZAD gathers experts in the fields of biosecurity, virology, pathobiology and related fields in order to educate promising students who are interested in those fields. Most of the sessions take place at the Biosecurity Research Institute at Kansas State University. The event also features visits to various industry, business and educational sites within the Kansas City Animal Health Corridor.

The participants, most of them post-graduate students, are involved in the study of various research methods into infectious diseases. Their names, schools and current majors are:

  • Gregory Stapleton, Cornell University College of Veterinary Medicine, DVM.
  • Katelyn Haydett, Michigan State University, DVM.
  • Sarah Murray, Texas A&M, PhD.
  • Megan Toms, Virginia-Maryland College of Veterinary Medicine, DVM/MPH.
  • Jonathan Teeple, Michigan State University, DVM/MPH.
  • Dana Stewart, Michigan State University DVM/MPH.
  • Grayson Walker, North Carolina State University, DVM/PHD.
  • Madeline Butterfield, University of South Dakota, BS in medical biology and Kansas State University DVM student.
  • Andrea Ayala, University of Georgia, PhD in comparative biomedical sciences.
  • Elsa Sanabria, North Carolina State University, DVM/MPH.

April 16, 2019

Position Opening at University of Pittsburgh

The University of Pittsburgh Health Sciences has a Postdoctoral Associate opening in their School of Medicine/Pediatrics. Major area of investigation for this position is the immunity and pathogenesis of Rift Valley fever virus. Specific areas of interest include: a) the role of viral tropism in pathogenesis b) the function of CD4 T cells in prevention of RVFV mediated encephalitis c) development and evaluation of vaccines and therapeutics to ameliorate RVFV disease.

The candidate should have a Ph.D. degree and be familiar with basic techniques in molecular biology, virology, and immunology. Research experience in virology, T cell immunology and flow cytometry, and mouse work is highly desirable.

Check out the full job posting here:

https://ppp.hs.pitt.edu/ViewPost.aspx?q=1104


April 3, 2019

CEEZAD research is focus of article in March issue of Vaccines

A recent vaccine study conducted by researchers at the Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD) was highlighted on the cover in the March issue of "Vaccines", an international peer-reviewed journal focusing on laboratory and clinical research.


The article’s co-authors are Sun-Young Sunwoo, Daniel Perez-Nunez, Igor Morozov, Elena Sanchez, Natasha Gaudreault, Jessie Trujillo, Lina Mur, Marissa Nogal, Daniel Madden, Kinga Urbanek, In Joong Kim, Wenjun Ma, Yolanda Revilla and Juergen Richt. All are either CEEZAD researchers or collaborators from CBMSO in Madrid, Spain.


The study focuses on CEEZAD efforts to develop a vaccine for African Swine Fever Virus (ASFV), a mostly fatal disease of swine for which there is no commercially available vaccine. Recent outbreaks of the virus in Trans-Caucasus countries, Russia, Eastern Europe, Belgium, Vietnam and China highlight the urgent need to develop efficacious vaccines against ASFV.


In the article’s abstract, the authors note that they have previously evaluated the immunogenicity of a vaccination strategy designed to test various combinations of ASFV antigens encoded by DNA plasmids and recombinant proteins with the aim to activate both humoral and cellular immunity. Based on those results, this most recent study was designed to test the efficacy of a combined DNA-protein vaccine strategy using a cocktail of the most immunogenic antigens against virulent ASFV challenge.


The results point to a putative immune enhancement mechanism involved in ASFV pathogenesis that warrants further investigation. The authors said the pilot study provides insights for the selection of appropriate combinations of ASFV antigens for the development of a rationally-designed, safe, and efficacious vaccine for ASF.


March 28, 2019

 

Dr. Juergen A. Richt, director of CEEZAD, explains recent findings of a research study developing a vaccine for Rift Valley Fever Virus vaccine during FRONTIERS, a University of Kansas-sponsored day committed to highlighting research on recent regional laboratory discoveries in the field of medical science. Dr. Richt explained the major findings of the CEEZAD research program (including Rift Valley Fever, Avian Flu and African Swine Fever) during the event, held during the last week of March in Kansas City.


March 7, 2019

CEEZAD’s director delivers keynote address at Gordon Research Conference

The director of the Center of Excellence for Emerging and Zoonotic Animal Diseases delivered the keynote address at this week’s Chemical and Biological Terrorism Gordon Research Conference held in Ventura, Calif.

Dr. Juergen Richt addressed conferees Sunday on the topic, “Rift Valley Fever: Development of Mitigation Strategies in Target Animals.” In his address, he discussed research efforts underway at the Richt Lab to develop target animal models for Rift Valley Fever and safe and efficacious vaccines. One focus of his presentation was familiarization of participants with ongoing research efforts at the Kansas State University-based Biosecurity Research Institute.

Rift Valley Fever is a vector-borne disease in ruminants, also capable of affecting humans. It is most commonly found in eastern and southern Africa and the Arabian peninsula.

During a Monday session, Dr. Richt also led a discussion on agro-terrorism, which are terrorist acts intended to disrupt or damage a country's agricultural system, especially the use of a biological agent against crops or livestock.

The conference, which has attracted biosecurity researchers from around the world, has been held every other year since 1998. Its purpose is to focus on the application of cutting edge research and apply that research to the development of new anti-terrorism tools. Major conference topics include novel imaging techniques that follow host response to chemical and biological insults, novel approaches to countering antimicrobial resistance, new detection technologies and the integration of understanding the problems and advances in agriculture bioterrorism.


February 16, 2019

Director of CEEZAD recognized as 2018 AAAS Fellow at ceremony in Washington D.C.

On February 16, Dr. Juergen Richt was pinned by the American Association for the Advancement of Science at their annual meeting in Washington, D.C.

A Regents distinguished professor and the director of Kansas State University's Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD), Dr. Richt was selected for his distinguished research and advisory contributions to the field of zoonotic diseases - particularly for his pioneering role in the development of the One Health paradigm.

Dr. Richt is a veterinary microbiologist who has worked with multiple agents of zoonotic potential, including bovine spongiform encephalopathy or mad cow disease, chronic wasting disease, animal influenza viruses, Rift Valley Fever virus, Borna virus and other emerging pathogens. He has been published extensively, with authorship or co-authorship of over 200 per-reviewed articles.

Election as a fellow is an honor bestowed upon association members by their peers. The association's fellowship program recognizes individuals whose efforts toward advancing science applications are deemed scientifically or socially distinguished.

Out of the 416 fellows elected this year, seven were faculty at veterinary colleges in the U.S. (including Dr. Richt). There was also an additional fellow from Kansas State University – Dr. Jame Guikema, a late professor of biology and University administrator.

Read more about the 2018 veterinary fellows here:

https://www.avma.org/News/JAVMANews/Pages/190215n.aspx


January 7, 2019