The Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD) at Kansas State University was established in 2010 to help protect the nation’s agricultural and public health sectors against a high-consequence foreign animal, emerging and zoonotic disease threats. CEEZAD has four principal missions:
- Development of novel, safe, efficacious, and DIVA-compatible vaccines for prevention and control of high-impact emerging and zoonotic diseases that can be manufactured in the U.S.
- Development and expansion of technologies and platforms for laboratory and point-of-need pathogen detection.
- Development of models to predict high-consequence disease behavior in the U.S. to aid prevention or outbreak control.
- Development of education and training programs for students, veterinarians, first responders, and researchers in high-impact animal diseases and animal emergencies.
January 4, 2023
CEEZAD researchers advance understanding of spread of African Swine Fever Virus in Mongolia
An article co-authored by the Director of the Center of Excellence for Emerging and Zoonotic Animal Diseases (www.ceezad.org) and the Center on Emerging and Zoonotic Infectious Diseases (CEZID; https://www.k-state.edu/cezid/) sheds new light on the African Swine Fever virus which spread in domestic pigs in Mongolia.
The article was co-authored by Dr. Juergen A. Richt, Regents and University Distinguished Professor at Kansas State University and director of CEEZAD and CEZID. It was published in the December 2022 edition of Viruses.
Other co-authors included Natasha Gaudreault, Konner Cool, Jessie Trujillo, Igor Morozov, David Meekins, Chester McDowell, Dashzeveg Bold, Velmurugan Balaraman, Taeyong Kwon, Daniel Madden, Bianca L. Artiaga, Cassidy Keating, Jamie Retallick and Jayme A. Souza-Neto, all of the Department of Diagnostic Medicine and Pathology at Kansas State University and CEEZAD.
African swine fever (ASF) is an infectious viral disease caused by African swine fever virus (ASFV), that causes high mortality in domestic swine and wild boar (Sus scrofa). Currently, outbreaks are mitigated through strict quarantine measures and the culling of affected herds, resulting in massive economic losses to the global pork industry.
In 2019, an ASFV outbreak was reported in Mongolia, describing a rapidly progressing clinical disease and gross lesions consistent with the acute form of ASF.
Due to the limited information on clinical disease and viral dynamics in swine available from field observations of the Mongolian isolates, CEEZAD researchers conducted the present study to further evaluate the progression of clinical disease, virulence, and pathology of an ASFV Mongolia/2019 field isolate (ASFV-MNG19), by experimental infection of domestic pigs. Intramuscular inoculation of domestic pigs with ASFV-MNG19 resulted in clinical signs and viremia at 3 days post challenge (DPC).
Clinical disease rapidly progressed, resulting in the humane euthanasia of all pigs by 7 DPC. ASFV-MNG19 infected pigs had viremic titers of 108 TCID50/mL by 5 DPC and shed virus in oral secretions late in disease, as determined from oropharyngeal swabs.
Whole-genome sequencing confirmed that the ASFV-MNG19 strain used in this study was a genotype II ASFV strain highly similar to other regional strains.
The results demonstrate that ASFV-MNG19 is a virulent genotype II ASFV strain that causes acute ASF in domestic swine. The full article can be viewed by following this link: https://pubmed.ncbi.nlm.nih.gov/36560702/#:~:text=Viruses,doi%3A%2010.3390/v14122698